anti-CD68 Molecule (CD68) antibody: CD68 is a transmembrane glycoprotein of 110kD, with a large expression in monocytes and human tissues. Is a member of the family of lysosomal membrane-associated glycoprotein / endosomal (LAMP). The protein located mainly lysosomes and endosomes with a circulating fraction to the cell surface. Is an integral membrane protein with a Type I strongly glycosylated extracellular domain which binds to lectins or tissues and specific organs selectins. The protein is also a member of the family of scavenger receptors. The typical function of scavenger receptors is to clean the cell debris, and promotion of phagocytosis mediate the recruitment and activation of macrophages. There results of alternative connections in multiple transcripts that encode different isoforms. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.
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