anti-CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) antibody: CD79a (IGBP1, Alpha 4 protein) is initially expressed at the pre B cell stage and persists until the plasma cell stage, where it is found as an intracellular component. CD79a associates with surface IgM-receptors, it has been implicated in signal transduction pathways and in the regulation of type 2A- related serine/threonine phosphatases catalytic activity. A disulfide-linked heterodimer, consisting of CD79a / mb-1 and CD79b / B29 polypeptides, non-covalently associates with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a is found in the majority of acute leukemias of precursor B cell type, B cell lines, B cell lymphomas, and some myelomas. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.
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