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Anti-CD8 monoclonal antibody, clone 49.76 [FITC]

Anti-CD8 monoclonal antibody, clone 49.76 [FITC]

Cat no: DMABT-45291MS

Supplier: Creative Diagnostics
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Mouse anti-Sheep CD8 monoclonal antibody for FC. CD8 is a 68 kDa disulphide-linked, transmembrane glycoprotein. The CD8 molecule serves as a receptor for MHC class I molecules and can mediate a function as a coreceptor in TCR-ligand binding and T-cell activation. Its cytoplasmic part is associated with the p56lck tyrosine kinase. CD8 is expressed by the great majority of cortical thymocytes and approximately 30% of medullary thymocytes, and by class I major histocompatibility complex restricted, mature suppressor/cytotoxic T cells. In addition a proportion of ?? T cells and NK cells express CD8. Thus, CD8 is expressed by about 25-35% of peripheral T cells, and about 30% of NK cells express low levels of CD8. Immunophenotyping of lymphocytes is widely applied as a component of the testing of peripheral blood for diagnosis of immunodeficiencies such as aquired immunodeficiency syndrome (AIDS). An increase in the percentage of CD8-positive T cells has been reported during cytomegalovirus infection.
Catalogue number: DMABT-45291MS
Reactivities: Bovine, Goat, Sheep
Hosts: Mouse
Clone: 49.76
Gene: 925
Target: CD8A
Isotype: IgG2a
Clonality: Monoclonal
Storage temp: Store at +4 oC or at -20 oC if preferred.This product should be stored undiluted.Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

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