Anti-CENPT (phospho S47) polyclonal antibody

Rabbit Anti-Human CENPT polyclonal antibody for ICC, WB, Dot. Centromere protein T (UniProt Q96BT3; also known as CENP-T, Interphase centromere complex protein 22) is encoded by the CENPT (also known as C16orf56, ICEN22) gene (Gene ID 80152) in human. Kinetochore complex-mediated chromosome interaction with microtubules from the mitotic spindle is essential for proper chromosome segregation during mitosis. The kinetochore is a macromolecular structure composed of almost 100 different proteins assembled upon the centromere in a cell cycle-regulated manner. CENP-T and 15 other chromatin proximal proteins constitute the Constitutive Centromere Associated Network (CCAN) present at centromeres throughout the cell cycle. Some CCAN proteins (e.g. CENPT/W complex and CENP-C) mediate DNA binding, while others (e.g. CENP-N) interact directly with CENP-A-containing nucleosomes. Evidence suggests that CENP-C and the CENP-T/W complex function as core kinetochore assembly factors in vertebrate cells.

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SPECIFICATIONS

Catalog Number

CABT-B1622

Hosts

Rabbit

Reactivities

Hum

Target

CENPT

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20В°C may cause glycerol containing solutions to become frozen during storage.