Rabbit Anti-Human CHMP4A polyclonal antibody for WB. CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are;components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of;surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and;cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and;regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).