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Anti-COL4A3 (native) polyclonal antibody

Cat no: CABT-BL1117

Anti-COL4A3 (native) polyclonal antibody

Rabbit Anti-Pig COL4A3 polyclonal antibody for IHC, IF, ELISA, RIA. Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

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SPECIFICATIONS

Catalog Number

CABT-BL1117

Applications

ELISA

Hosts

Rabbit

Conjugates

Unconj

Target

COL4A3

Gene Id

397502

Clonality

Polyclonal

Storage Temp

Store at 4В°C on dry atmosphere.After reconstitution with deionized water, store at -20В°C or lower. Aliquot to avoid repeated freezing and thawing.

SUPPLIER INFO

Creative Diagnostics

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