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Anti-CPD (aa1169-1374) polyclonal antibody

Cat no: CABT-B043

Anti-CPD (aa1169-1374) polyclonal antibody

Rabbit Anti-CPD (aa1169-1374) polyclonal antibody for WB, IF, IP. Carboxypeptidase D (CPD) is a membrane glycoprotein with a single hydrophobic transmembrane anchor near the C-terminus and three tandem carboxypeptidase homology domains. Domains 1 and 2 are catalytically active but domain 3 is not. CPD cleaves only C-terminal Arg or Lys residues from proteins and has an acidic pH optimum of ~ 6.0. CPD is ubiquitously expressed and is especially high in macrophages. CPD is predominantly localized in the trans-Golgi and is involved in peptide and protein processing in the constitutive secretory pathway after initial furin cleavage and is also involved in processing microbial toxins such as Pseudomonas exotoxin. Drosophila lacking CPD die in the larval stage and CPD is an important target gene of TGF-? in macrophages that is downregulated in lupus erythematosus. CPD-mediated generation of L-Arg enhances iNOS-dependent NO generation in mouse macrophages and promote NO production and cell survival in breast cancer cells.

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SPECIFICATIONS

Catalog Number

CABT-B043

Hosts

Rabbit

Reactivities

Hum, Mouse

Target

CPD

Gene Id

1362

Clonality

Polyclonal

Storage Temp

-20В°C

SUPPLIER INFO

Creative Diagnostics

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