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Anti-DOCK3 polyclonal antibody

Cat no: CABT-BL1307

Anti-DOCK3 polyclonal antibody

Rabbit Anti-Human DOCK3 polyclonal antibody for IHC, IF. This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]

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SPECIFICATIONS

Catalog Number

CABT-BL1307

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Target

DOCK3

Gene Id

1795

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Store at 4В°C. For long term storage store at -20В°C. Aliquot to avoid repeated freezing and thawing.

SUPPLIER INFO

Creative Diagnostics

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