Mouse Anti-Enterovirus VP1 Monoclonal antibody. Enteroviruses are agenus of (+)ssRNA viruses associated with several human and mammaliandiseases. Serologic studies have distinguished 66 human enterovirus serotypeson the basis of antibody neutralization tests. Additional antigenic variantshave been defined within several of the serotypes on the basis of reduced ornonreciprocal cross-neutralization between variant strains. On the basis oftheir pathogenesis in humans and animals, the enteroviruses were originallyclassified into four groups, polioviruses, Coxsackie A viruses (CA),Coxsackie B viruses (CB), and echoviruses, but it was quickly realized thatthere were significant overlaps in the biological properties of viruses inthe different groups. Enteroviruses isolated more recently are named with asystem of consecutive numbers: EV68, EV69, EV70, and EV71, etc. Enterovirusesaffect millions of people worldwide each year, and are often found in therespiratory secretions (e.g., saliva, sputum, or nasal mucus) and stool of aninfected person. Historically, poliomyelitis was the most significant diseasecaused by an enterovirus, Poliovirus. There are 62 non-polio enterovirusesthat can cause disease in humans: 23 Coxsackie A viruses, 6 Coxsackie Bviruses, 28 echoviruses, and 5 other enteroviruses. Poliovirus, as well ascoxsackie and echovirus are spread through the fecal-oral route. Infectioncan result in a wide variety of symptoms ranging from mild respiratoryillness (common cold), hand, foot and mouth disease, acute hemorrhagicconjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-likedisease, and acute flaccid paralysis.
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