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Anti-EPB49 (full length) polyclonal antibody

Cat no: CABT-BL4586

Anti-EPB49 (full length) polyclonal antibody

Mouse Anti-Human EPB49 (full length) polyclonal antibody for WB. The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3 coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

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SPECIFICATIONS

Catalog Number

CABT-BL4586

Hosts

Mouse

Reactivities

Hum, Rat

Conjugates

Unconj

Target

EPB49

Gene Id

2039

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Store at -20В°C or lower. Aliquot to avoid repeated freezing and thawing.

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