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Anti-ERCC6L (full length) polyclonal antibody

Anti-ERCC6L (full length) polyclonal antibody

Cat no: CABT-BL1391

Supplier: Creative Diagnostics
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Mouse Anti-Human ERCC6L polyclonal antibody for WB. Plk1-interacting checkpoint helicase (PICH ) is an essential component of the spindle assembly checkpoint (Baumann, C., et al. (2007). Cell 128:101–114). This protein is an ATPase family SNF2 member, and serves as a binding partner and substrate for Plk1. When PICH is phosphorylated, it retrieves Plk1 which serves to mediate the localization of PICH. As a DNA helicase, PICH gathers at kinetochores and centromeres during prometaphase, acting as a necessary part of the spindle assembly checkpoint by recruiting MAD2 and mediating chromatin centromeric tension. Depleted PICH results in the cancellation of the spindle checkpoint causing large scale missegregation of the chromosome.
Catalogue number: CABT-BL1391
Reactivities: Human
Hosts: Mouse
Conjugates: Unconjugated
Gene: 54821
Target: ERCC6L
Isotype: IgG
Clonality: Polyclonal
Storage temp: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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