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Anti-Ezrin-Radixin-Moesin polyclonal antibody

Cat no: DPAB3659


Supplier: Creative Diagnostics
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Rabbit anti-Human Ezrin-Radixin-Moesin polyclonal antibody for WB, IP, IHC, ICC, FC. The ERM family consists of three closely related proteins, ezrin, radixin, and moesin (ERM proteins). Ezrin (82 kDa) was enriched in microvilli of cells. Radixin (80 kDa) is a component of adherent junctions. Moesin (75 kDa) was isolated from bovine uterus abundant in smooth muscle cells as a heparin-binding protein. Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, it is required for normal macropinocytosis. Ezrin plays a key role in cell surface structure adhesion, migration and organization. It has been implicated in various human cancers.There are active (insoluble) and inactive (soluble) forms of ERM proteins in terms of their cross-linking activity inside cells. The cross-linking activity of ERM proteins between actin filaments and plasma membranes is dynamically regulated. In ERM proteins, the N-terminal FERM domain is followed by an extended ?-helical domain and a charged C-terminal domain, which includes a consensus sequence motif for actin binding. The N- and C-terminal halves of ERM proteins mutually interact intramolecularly and suppress their actin filament and membrane binding activities. Some activation signal may release this suppression to activate ERM proteins inside cells.
Catalogue number: DPAB3659
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Target: Ezrin / Radixin / Moesin
Isotype: IgG
Clonality: Polyclonal
Storage temp: Store at -20oC, 4oC for frequent use. Avoid repeated freeze-thaw cycles.

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