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Anti-F2RL1 monoclonal antibody, clone 455333

Anti-F2RL1 monoclonal antibody, clone 455333

Cat no: CABT-B8953

Supplier: Creative Diagnostics
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Mouse Anti-Human F2RL1 monoclonal antibody for FC. Protease-Activated Receptor 2 (PAR2) is a protease activated 7-transmembrane G-protein-coupled receptor. Human PAR2 contains a cleavage site for trypsin, mast cell tryptase or coagulation factor VIIa or Xa, 11 amino acids (aa) C-terminal to the signal sequence. Cleavage creates a tethered ligand that activates the 361 aa receptor. PAR2 is expressed in kidney, pancreas, stomach, intestine, airway, skin, bladder and brain; activation stimulates release of inflammatory and nociceptive mediators. PAR2 is downregulated by ubiquination, endocytosis and degradation. Mature human PAR2 shows 78% amino acid identity with mouse PAR2 over the extracellular portions.
Catalogue number: CABT-B8953
Reactivities: Human
Hosts: Mouse
Clone: 455333
Gene: 2150
Target: F2RL1
Isotype: IgG2a
Clonality: monoclonal
Storage temp: 12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
6 months, -20 to -70°C under sterile conditions after reconstitution.

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