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Anti-F2RL1 monoclonal antibody, clone 455333

Cat no: CABT-B8953

Anti-F2RL1 monoclonal antibody, clone 455333

Mouse Anti-Human F2RL1 monoclonal antibody for FC. Protease-Activated Receptor 2 (PAR2) is a protease activated 7-transmembrane G-protein-coupled receptor. Human PAR2 contains a cleavage site for trypsin, mast cell tryptase or coagulation factor VIIa or Xa, 11 amino acids (aa) C-terminal to the signal sequence. Cleavage creates a tethered ligand that activates the 361 aa receptor. PAR2 is expressed in kidney, pancreas, stomach, intestine, airway, skin, bladder and brain; activation stimulates release of inflammatory and nociceptive mediators. PAR2 is downregulated by ubiquination, endocytosis and degradation. Mature human PAR2 shows 78% amino acid identity with mouse PAR2 over the extracellular portions.

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SPECIFICATIONS

Catalog Number

CABT-B8953

Hosts

Mouse

Reactivities

Hum

Clone

455333

Target

F2RL1

Gene Id

2150

Isotype

IgG2a

Clonality

monoclonal

Storage Temp

12 months from date of receipt, -20 to -70В°C as supplied.<br/>1 month, 2 to 8В°C under sterile conditions after reconstitution.<br/>6 months, -20 to -70В°C under sterile conditions after reconstitution.

SUPPLIER INFO

Creative Diagnostics

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