Anti-FOXK2 polyclonal antibody

Rabbit Anti-Human FOXK2 polyclonal antibody for WB, IP. Forkhead box protein K2 (UniProt Q01167; also known as FOXK2, Cellular transcription factor ILF-1, Interleukin enhancer-binding factor 1) is encoded by the FOXK2 (also known as ILF, ILF-1, ILF1) gene (Gene ID 3607) in human. FOXK2 is a transcription factor involved in cell proliferation and survival. FOXK1 and FOXK2 belong to the family of Fox transcription factors characterized by the forkhead DNA-binding domains. However, FOXK1 and FOXK2 can be distinguished from other Fox transcription factors by the presence of the forkhead-associated (FHA) domains. FOXK2 interacts with BRCA1-associated protein 1 (BAP1) through the FHA domain in a BAP1 Thr493 phosphorylation-dependent manner. BAP1 in turn recruits HCF-1, thereby forming a ternary complex at the FOXK2 target genes sites, where BAP1 represses FOXK2 target genes expression in a BAP1 DUB activity-dependent manner.

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SPECIFICATIONS

Catalog Number

CABT-B1904

Hosts

Rabbit

Reactivities

Hum

Target

FOXK2

Gene Id

3607

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.