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anti-Glial Fibrillary Acidic Protein (GFAP) antibody

Cat no: ABIN1020294

anti-Glial Fibrillary Acidic Protein (GFAP) antibody

anti-Glial Fibrillary Acidic Protein (GFAP) antibody: Glial fibrillary acidic protein (GFAP), is one of the fibrillary proteins which stains the intermediate filaments from the intracellular cytoskeleton, particularly glial cells such as astrocytes and Schwann cells. GFAP was first described in 1971, it is a type III protein codified by a gene, which in humans is located on the 17 chromosome. Its main function is protecting the rigid organization of the intern 3D structure from brain astrocytes, enabling kind of flexibility and curvature. In many cells GFAP is straightly related with vimentin, desmin, and peripherin, which takes part of the structure and function of the cytoskeleton. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.

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SPECIFICATIONS

Catalog Number

ABIN1020294

Size

1 mL

Applications

IHC, IHC-F

Hosts

Rabbit

Antigen

GFAP (Glial Fibrillary Acidic Protein)

Gene Id

14580,24387,30646,419969,100172719,2670,480495,100033970,396562,281189,100720409,100352532

Isotype

IgG

Clonality

Polyclonal

Entrez Gene Id

14580,24387,30646,419969,100172719,2670,480495,100033970,396562,281189,100720409,100352532

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