Anti-GPR98 polyclonal antibody

Rabbit Anti-Human GPR98 polyclonal antibody for IHC. G-protein coupled receptor 98 (UniProt Q8WXG9; also known as Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1) is encoded by the GPR98 (also known as KIAA0686, KIAA1943, MASS1, USH2C, VLGR1) gene (Gene ID 84059) in human. GPR98, also known as Very Large GPCR receptor 1 (Vlg1R1), is the largest G-protein-coupled receptor (GPCR) known. It is an adhesion-GPCR family receptor expressed in the central nervous system. GPR98 is produced with a signal peptide (a.a. 1-29) sequence, the removal of which yields the mature seven-transmembrane (a.a. 5909-5929, 5940-5960, 5980-6000, 6011-6031, 6060-6080, 6105-6125, 6134-6154) protein with a C-termiinal cytoplasmic domain (a.a. 6155-6306) and a large N-terminal extracellular region (a.a. 30-5908) that contains six epilepsy-associated repeats or EAR domains (a.a. 3189-3534) sandwiched between two clusters of calcium-binding Calx-beta repeats (Calx-beta 1-22/a.a. 30-3172 and Calx-beta 23-35/a.a. 3525-5468), as well as a GPCR-proteolytic site (GPS; a.a. 5853-5902) proximal to the first transmembrane helix. The extreme carboxy-terminus contains a consensus PDZ ligand sequence, suggesting interactions with other cytosolic or cytoskeletal proteins. Although the GPR98 ligand is yet to be identified, GPR98 gene mutations are linked to one form (2C) of Usher syndrome, the most common genetic cause of combined blindness and deafness.

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