Anti-GRASP55 polyclonal antibody

Cat no: CABT-B1945

Supplier: Creative Diagnostics

0 reviews | Write a Review Pencil

Read More on Supplier Website

Description
Additional Information

Rabbit Anti-Rat GRASP55 polyclonal antibody for WB, ICC. Golgi reassembly stacking protein of 55 kDa (also called Golgi reassembly-stacking protein of 55 kDa, GRASP55, or Grs2) is encoded by the gene designated as Gorasp2 in rat & mouse (GORASP2/GRS2/GOLPH6 in human). Golgi stack formation involves two homologous peripheral Golgi proteins, GRASP55 and GRASP65, localized to the medial-trans and cis cisternae, respectively. GRASP55 and GRASP65 stack mammalian Golgi cisternae via a common mechanism of phosphorylation-regulated oligomerization. GRASP55 stacks Golgi membranes by forming oligomers through its N-terminal GRASP domain. This process is regulated by phosphorylation within the C-terminal serine/proline-rich domain. Expression of nonphosphorylatable GRASP55 mutants enhances Golgi stacking in interphase cells and inhibits Golgi disassembly during mitosis. Knockdown of either GRASP55 or GRASP65 by siRNA reduces the number of cisternae per Golgi stack, while simultaneous knockdown of both GRASP proteins leads to disassembly of the entire stack.

Catalogue number:	CABT-B1945
Reactivities:	Human, Mouse, Hamster
Hosts:	Rabbit
Target:	GORASP2
Clonality:	Polyclonal
Storage temp:	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

See Full Product Listings >

Anti-GRASP55 polyclonal antibody

Cat no: CABT-B1945

Get Quote

About Biosave

Product Categories

Information


Get a Quote Direct from Creative Diagnostics




By submitting this form you agree to your details being passed to Creative Diagnostics for the purpose of generating the best quote*