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Anti-GRHL3 (C-terminal half) polyclonal antibody

Cat no: CABT-B1710

Anti-GRHL3 (C-terminal half) polyclonal antibody

Rabbit Anti-Human GRHL3 polyclonal antibody for WB, ICC, IP. Grainyhead-like protein 3 homolog (UniProt Q8TE85; also known as Sister of mammalian grainyhead, Transcription factor CP2-like 4) is encoded by the GRHL3 (also known as SOM, TFCP2L4, VWS2) gene (Gene ID 57822) in human. Mammalian grainyhead-like (GRHL1, GRHL2, and GRHL3) genes code for transcription factors and are named after their drosophila homolog grainyhead (GRH). These factors show tissue- and developmental stage-dependent expression patterns. Grainyhead-like 3 (GRHL3) is reported to play a protective role against squamous cell carcinoma (SCC) of the skin. Tumor suppressor phosphatase and tensin homolog (PTEN) is a direct target of GRHL3, Grhl3-knockdown in mice causes skin tumor formation as a result of reduced Pten expression. Consistently, downregulated GRHL3 and PTEN levels are found in human SCC skin samples. In addition, GRHL3 is a positive regulator of E-cadherin expression during mesenchymal epithelial transition (MET) in non-tumorigenic mammary gland cells, as well as in breast and lung cancer cells. High GRHL3 expression is found in early stages of breast cancer and the expression is greatly reduced in advanced stages of breast cancer.

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SPECIFICATIONS

Catalog Number

CABT-B1710

Hosts

Rabbit

Reactivities

Hum

Target

GRHL3

Gene Id

57822

Clonality

Polyclonal

Storage Temp

Stable for 1 year at 2-8В°C from date of receipt.

SUPPLIER INFO

Creative Diagnostics

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