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anti-Histone H2A Variant (HIS2AV) (pSer137), (Internal Region) antibody

Cat no: ABIN964669

anti-Histone H2A Variant (HIS2AV) (pSer137), (Internal Region) antibody

anti-Histone H2A Variant (HIS2AV) (pSer137), (Internal Region) antibody: Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. H2AvD is vital for viability, but the exact function of variant histones H2A is not known. H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 bp of DNA. HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only). The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur. In mouse, H2AX ''knock out'' mice have an increased incidence of cancer.

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SPECIFICATIONS

Catalog Number

ABIN964669

Size

25 micro L

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Dro/Arth

Antigen

Histone H2AvD

Gene Id

43229

Isotype

IgG

Accession

P08985

Clonality

Polyclonal

Concentration

1.0 mg/ml

Entrez Gene Id

43229

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