Anti-IFIT3 polyclonal antibody

Rabbit Anti-Mouse IFIT3 polyclonal antibody for WB, ICC, FC, IHC-P, IP. Interferon-induced protein with tetratricopeptide repeats 3 (UniProt Q64345; also known as GARG-49, Glucocorticoid-attenuated response gene 49 protein. IFIT-3, IRG2, p49) is encoded by the Ifit3 (also known as Garg49, Ifi49, Isg49) gene (Gene ID 5959) in murine species. IFIT1, IFIT2, and IFIT3 constitute the family of interferon-stimulated genes (ISGs) that are induced in response to virus infection, stimulation by interferons (IFNs), or double-stranded RNA (dsRNA). The proteins encoded by IFIT1 and IFIT2 are called ISG56 (p56) and ISG54 (p54) in both human and murine species, while the protein encoded by IFIT3 is of a different size in murine (ISG49 or p49) than its human counterpart (ISG60 or p60). Studies conducted in murine species reveals that the three members exhibit distinct properties and induction patterns in different cell types. While all three murine proteins are shown to bind the c-subunit of the translation initiation factor eIF3, p49/Ifit3 does not inhibit protein synthesis as p56/Ifit1 and p54/Ifit2.

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SPECIFICATIONS

Catalog Number

CABT-B1908

Hosts

Rabbit

Reactivities

Hum, Mouse

Target

IFIT3

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.