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Anti-IKK alpha polyclonal antibody

Cat no: CABT-B1934

Anti-IKK alpha polyclonal antibody

Rabbit Anti-Human IKK alpha polyclonal antibody for WB, ICC. IKK-alpha (I-Kappa-B kinase-alpha) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. Activation of NFKB by TNF requires phosphorylation of IKKalpha at threonine 23 and serine 176 by AKT1 and NIK respectively. It has been demonstrated that IKK-alpha can accumulate in the nucleus after cytokine exposure. In the nucleus IKK-alpha interacts with CREB-binding protein in conjunction with RELA to be recruited to the NF-kappa-B-responsive promoters in order to mediate the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone H3.

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SPECIFICATIONS

Catalog Number

CABT-B1934

Hosts

Rabbit

Reactivities

Hum

Target

CHUK

Gene Id

1147

Clonality

Polyclonal

Storage Temp

Stable for 1 year at 2-8В°C from date of receipt.

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