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Anti-IL12RB1 polyclonal antibody

Cat no: CABT-BL010

Anti-IL12RB1 polyclonal antibody

Rabbit Anti-Human IL12RB1 polyclonal antibody for WB, IHC, IF. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

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SPECIFICATIONS

Catalog Number

CABT-BL010

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Target

IL12RB1

Gene Id

3594

Isotype

IgG

Clonality

polyclonal

Storage Temp

Store at -20В°C. Avoid freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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