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anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody

Cat no: ABIN1043820

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody

anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody: Anti-IDO-1 antibody recognizes indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.

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SPECIFICATIONS

Catalog Number

ABIN1043820

Size

25 micro L

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

Reactivities

Mouse

Clone

2E2.6

Antigen

IDO1

Gene Id

15930

Isotype

IgG1

Accession

P28776

Clonality

Monoclonal

Concentration

0.95 mg/mL

Entrez Gene Id

15930

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