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anti-Interleukin 10 (IL10) antibody

Cat no: ABIN1043703

anti-Interleukin 10 (IL10) antibody

anti-Interleukin 10 (IL10) antibody: Anti IL-10 Antibody recognizes IL-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), that is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. IL-10 is produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappaB activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract and indeed patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin 10, showing the importance of interleukin 10 for counteracting excessive immunity in the human body. Anti-IL-10 cytokine antibody is ideal for investigators involved Immunology and Signal Transduction research.

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SPECIFICATIONS

Catalog Number

ABIN1043703

Size

25 micro L

Applications

BNI, ELISA, IHC, IP, RIA, WB

Hosts

Rabbit

Reactivities

Hum

Antigen

IL-10

Gene Id

3586

Accession

P22301

Clonality

Polyclonal

Concentration

80 mg/mL

Entrez Gene Id

3586

SUPPLIER INFO

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