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anti-Interleukin 17F (IL17F) antibody

Cat no: ABIN1043786

anti-Interleukin 17F (IL17F) antibody

anti-Interleukin 17F (IL17F) antibody: Anti-L-17F recognizes IL-17F (also known as Cytokine ML-1 or Interleukin-24). IL-17F is produced and secreted by CD8+ T cells, NK cells, NKT cells and LTi cells. The main functions of IL-17F are neutrophil recruitment and immunity to extracellular pathogen. More importantly, IL-17F drives inflammation and auto-immunity. IL-17A and IL-17F are by far the best characterized cytokines of the IL-17 cytokine family. IL-17F dimerizes in a parallel fashion similar to nerve growth factor and other neutrophins. Its dimerization is critical to fulfill its activity. When secreted by activated T cells, IL-17F can stimulate the production of other cytokines such as IL-6, IL-8 granulocyte colony-stimulating factor and, can stimulate cartilage matrix turnover. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. Anti-IL-17E cytokine antibody is ideal for investigators involved in Immunology, Signal Transduction research, Cancer and Inflammatory pathologies.

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SPECIFICATIONS

Catalog Number

ABIN1043786

Size

25 micro L

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

4H450.1

Antigen

IL-17F

Gene Id

112744

Isotype

IgG1

Accession

Q96PD4

Clonality

Monoclonal

Concentration

1.0 mg/mL

Entrez Gene Id

112744

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