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Anti-JNK (aa 172-190) polyclonal antibody

Cat no: DPAB2964


Supplier: Creative Diagnostics
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Rabbit anti-Human JNK (aa 172-190) polyclonal antibody for ELISA. c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They also play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. It has been suggested that this signaling pathway contributes to inflammatory responses in mammals and insects.
Catalogue number: DPAB2964
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Conjugates: Unconjugated
Target: JNK1
Isotype: IgG
Clonality: Polyclonal
Storage temp: -20°C. Avoid freeze/thaw

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