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anti-Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1) antibody (RPE)

Cat no: ABIN135352

anti-Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1) antibody (RPE)

anti-Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1) antibody (RPE): The antibody detects: KLRG1 (Mr 30-38 kDa) The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1, formerly known as mouse MAFA or 2F1-Ag), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60 % of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.

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SPECIFICATIONS

Catalog Number

ABIN135352

Size

0.1 mg

Applications

FC

Hosts

Ham

Reactivities

Mouse

Clone

2F1

Antigen

KLRG1/MAFA

Gene Id

50928

Isotype

IgG

Accession

O88713

Clonality

Monoclonal

Entrez Gene Id

50928

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