Mouse anti-drosophila Klarsicht Alpha Protein monoclonal antibody for IHC, IP. The Klarsicht (Klar) protein is a crucial factor in the regulation of bidirectional transport of lipid droplets. Lipid droplets in early embryos move bidirectionally along microtubules, and the balance of plus- and minus-end travel distances changes twice over a 2-h period, resulting in switches in the direction of net transport. In the absence of Klar, travel distances, travel velocities, and stall forces are greatly reduced, for both plus- and minus-end travel. Without Klar the motors for plus- and minus-end motion are active indiscriminately, engaging in a tug-of-war. Thus, Klar seems to be central for understanding how the activity of opposite-polarity motors is coordinated during bidirectional transport. In this system, Klar controls the minus-end motor cytoplasmic dynein and an as yet unknown plus-end motor.
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