Mouse anti-L-DOPA monoclonal antibody for ICC. L Dopa is anintermediate in dopamine biosynthesis. Clinically, L Dopa is used in themanagement of Parkinson"s disease. It is used as a prodrug to increasedopamine levels since it is able to cross the blood-brain barrier whereasdopamine itself cannot. Once L Dopa has entered the central nervous system(CNS), it is metabolised to dopamine by aromatic L amino acid decarboxylase.This also occurs in the peripheral tissues, causing adverse effects anddecreasing the available dopamine to the CNS, so it is standard practice toco administer a peripheral DOPA decarboxylase inhibitor and often acatechol-O-methyl transferase (COMT) inhibitor.
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