Rabbit Anti-Human LDB2 polyclonal antibody for ELISA, WB. Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact;with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 (PubMed 9799849)). These proteins, such as;the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to;function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to;block formation of such complexes (Jurata and Gill, 1997 (PubMed 9315627)). The family of genes encoding LIM;domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 (PubMed 9192866)) and;Clim2/Lbd1/Nli (Agulnick et al., 1996 (PubMed 8918878); Jurata et al., 1996 (PubMed 8876198); Bach et al., 1997;(PubMed 9192866)) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors;are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate;them in human phenotypes characterized by multiple affected sites.
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