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Anti-LIN28B (internal region) polyclonal antibody

Anti-LIN28B (internal region) polyclonal antibody

Cat no: CABT-BL2149

Supplier: Creative Diagnostics
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Rabbit Anti-Human LIN28B polyclonal antibody for WB, IHC, ELISA, FC. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5-GGAG-3 motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5-GGAG-3 motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
Catalogue number: CABT-BL2149
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Conjugates: Unconjugated
Gene: 389421
Target: LIN28B
Clonality: Polyclonal
Storage temp: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.

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