anti-Ly-49C/F/H/I antibody: The antibody detects: An epitope common to the Ly49C, Ly49F, Ly49H and Ly49I allelic/splice variants The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors.1 Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated.2 These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains approx. 90 % of NK1.1+CD3- splenocytes, and approx. 6 % of CD8+ spleen cells from C57BL/6 mice.1 The antibody also stains 30-80 % of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
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