Anti-Lysine Acetylated monoclonal antibody, clone 8G9

Mouse anti-Lysine Acetylated monoclonal antibody for ELISA, WB, IC. Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. A common posttranscriptional modification of lysine residues involves acetylation. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Protein posttranslational reversible lysine N?-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization. The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases. HDACs therefore are promising targets for anticancer drugs currently in development.

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

DMAB8429

Applications

ELISA

Hosts

Mouse

Conjugates

Unconj

Clone

8G9

Target

Lys

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store vial at -20В°C prior to opening. Aliquot contents and freeze at -20В°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for sever