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Anti-MAPK14 polyclonal antibody

Cat no: CABT-B8497

Anti-MAPK14 polyclonal antibody

Rabbit Anti-Human MAPK14 polyclonal antibody for ELISA, IHC, IP, WB. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation.

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SPECIFICATIONS

Catalog Number

CABT-B8497

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Target

MAPK14

Gene Id

1432

Clonality

Polyclonal

Storage Temp

-20В°C for long term storage

SUPPLIER INFO

Creative Diagnostics

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