anti-Mast/stem Cell Growth Factor Receptor (KIT) (C-Term) antibody

anti-Mast/stem Cell Growth Factor Receptor (KIT) (C-Term) antibody: CD117/c-Kit protein is a transmembrane tyrosine kinase receptor with high homology to the PDGFR protein family. It plays an important role in haematopoiesis, melanogenesis, and gametogenesis. CD117/c-Kit is expressed in ductal epithelia of the breast, melanocytes, mast cells, and glial cells as well as in small cell lung cancer, breast carcinoma, glioblastoma and melanoma. Antibodies to CD117/c-Kit are also suitable for characterisation of acute myeloid leukemia and detection of blast crisis in myeloid leukemia. In the light of new therapies for gastrointestinal stromal tumours (GIST) CD117/c-Kit has gained a growing importance in recent years. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.

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