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Anti-MBD1 (aa 593-605) polyclonal antibody

Anti-MBD1 (aa 593-605) polyclonal antibody

Cat no: CABT-BL2330

Supplier: Creative Diagnostics
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Rabbit Anti-Human MBD1 polyclonal antibody for WB, ChIP. Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone Lys-9 trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Catalogue number: CABT-BL2330
Reactivities: Human
Hosts: Rabbit
Applications: ChIP
Conjugates: Unconjugated
Gene: 4152
Target: MBD1
Isotype: IgG
Clonality: Polyclonal
Storage temp: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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