Anti-MERS-CoV Spike Protein S1 (N-terminal) polyclonal antibody

Rabbit Anti-MERS-CoV Spike Protein S1 (N-terminal) polyclonal antibody for WB, ELISA, IHC, IF, IP. The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

CABT-B1954

Applications

ELISA

Hosts

Rabbit

Target

MERS-CoV Spike Protein S1

Isotype

IgG

Clonality

polyclonal

Storage Temp

This antibody can be stored at 2В°C-8В°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20В°C to -80В°C. Preservative-Free. <br/>Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.