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anti-Nestin (NES) (AA 1484-1500), (Internal Region) antibody

Cat no: ABIN1043875

anti-Nestin (NES) (AA 1484-1500), (Internal Region) antibody

anti-Nestin (NES) (AA 1484-1500), (Internal Region) antibody: Nestin, is a large intermediate filament protein (class Type VI) that was first identified with a monoclonal antibody by Hockfield and McKay (1985). Nestin is expressed predominantly in stem cells of the central nervous system in the neural tube. Nestin is expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker, however, recent studies have found nestin expression in other cell types such as endothelial cells. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinomas. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments.

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SPECIFICATIONS

Catalog Number

ABIN1043875

Size

25 micro L

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Antigen

Nestin

Gene Id

10763

Isotype

IgG

Accession

P48681

Clonality

Polyclonal

Entrez Gene Id

10763

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