Anti-PEG monoclonal antibody, clone SN206

Rabbit anti-PEG monoclonal antibody for WB, IP, ICC, IHC, FC, ELISA. Polyethylene glycol(PEG)is a family of long chain polymers attached to a glycerine backbone. It is a nonionic, nontoxic, biocompatible, strongly hydrophilic polymer, which has a large exclusion volume in aqueous solution. The covalent attachment of PEG is now commonly used to modify a variety of proteins and drugs. The modification of a biopharmaceutical with polyethylene glycol (PEG) increases its hydrodynamic radius, reduces immunogenicity and proteolytic cleavage. Other benefits include decelerated renal excretion, improved stability towards proteolysis and increased solubility of the biopharmaceutical in aqueous solutions. As examples, PEG-adenosine deaminase (Adagen?) is used for the treatment of severe combined immunodeficiency syndrome, PEG asparaginase (Oncaspar?) is used for the treatment acute lymphoblastic leukemia, PEGвЂ“interferon ?2a (Pegasys?) is used for the treatment Hepatitis C, Branched PEGвЂ“anti-VEGF aptamer (Pegaptanib, Macugen?) is used for the treatment Macular degeneration(age-related). An Anti-PEG antibody can be used to monitor a drug's pharmacokinetics, including distribution, metabolism and excretion. In addition, it can be used for the quality control of pegylated molecules in ELISA, WB and flow cytometery.

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