Rabbit Anti-Human Phospholipase C polyclonal antibody for WB. Phospholipase C (PLC) is a class of enzymes that cleave phospholipids just before the phosphate group. It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Thirteen kinds of mammalian phospholipase C are classified into six isotypes (?, ?, ?, ?, ?, ?) according to structure.