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Anti-PION (aa 536-565) polyclonal antibody

Anti-PION (aa 536-565) polyclonal antibody

Cat no: CABT-BL2902

Supplier: Creative Diagnostics
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Rabbit Anti-Human PION polyclonal antibody for WB. Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of;amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or;GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both;gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF);(He et al., 2010 (PubMed 20811458)).
Catalogue number: CABT-BL2902
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 54103
Target: PION
Isotype: IgG
Clonality: Polyclonal
Storage temp: Store at 4°C (up to 6 months). For long term storage store at -20°C

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