anti-Progesterone Receptor (PGR) antibody

anti-Progesterone Receptor (PGR) antibody: Progesterone receptor (PR) is a protein regulated by estrogens, its sequence is coded by the chromosome 11q22. It has been proposed that determining the PR expression levels will show the activity of the ER mediated route, therefore it can predict the probably response against endocrine therapy in mammary carcinoma. Several studies have shown that determining these PR levels provides complementary information to the ER when have to predict the endocrine therapy response, as well as the patient survival estimation. In some other studies is presented superior to ER as a prognostic indicator. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.

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