Anti-Prothrombin monoclonal antibody, clone 30K4-73

Mouse Anti-Human Prothrombin monoclonal antibody for FC, Neut, ELISA. Prothrombin (EC3.4.21.5: UniProt P00734; also known as Coagulation factor II) is encoded by the F2 (also known as PT, THPH1, RPRGL2) gene (Gene ID 2147) in human. Prothrombin is initially produced with a signal sequence (a.a. 1-24) and a propeptide sequence (a.a. 25-43), the cleavage of which yields the prothrombin (PT) protein. PT is converted to the active serine protease thrombin by factor Xa in the coagulation cascade. The active thormbin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and XIII to XIIIa. PT is also one of several known anionic phospholipid-/aPL-binding proteins that exhibit apoptotic cells-selective affinity due to the presence of aPLs, such as phosphatidylserine (PS) and cardiolipin, on the outer leaflet of their palsma membrane. aPL autoantibodies are found in a variety of autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary anti-phospholipid syndrome (APS), characterized by clinical thrombosis and/or recurrent fetal loss. Although aPL autoantibodies were initially believed to target aPL directly, they are now thought to recognize primarily aPL-binding proteins, such as PT, ?2-glycoprotein I (?2GPI), and annexin V.

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SPECIFICATIONS

Catalog Number

CABT-B1271

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

Clone

30K4-73

Target

F2

Gene Id

2147

Isotype

IgG1

Clonality

Monoclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.