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Anti-PTEN monoclonal antibody, clone SN376

Anti-PTEN monoclonal antibody, clone SN376

Cat no: CABT-BL8498

Supplier: Creative Diagnostics
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Rabbit Anti-Human PTEN monoclonal antibody for IHC,WB. This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Catalogue number: CABT-BL8498
Reactivities: Human
Hosts: Rabbit
Clone: SN376
Gene: 5728
Target: PTEN
Isotype: IgG
Clonality: Monoclonal
Storage temp: Stable for 1 Year at -20.0°C from date of receipt

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