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Anti-Pyruvate Kinase (muscle) polyclonal antibody

Cat no: CABT-B1589

Anti-Pyruvate Kinase (muscle) polyclonal antibody

Rabbit Anti-Human Pyruvate Kinase polyclonal antibody for WB, ICC, IHC. Pyruvate kinases are cellular glycolytic enzymes that mediate glucose metabolism. There are four mammalian isoforms encoded by two gnens. The L gene is alternatively spliced to produce the L (liver) and R (erythrocyte) isoforms, while the M (muscle) gene is alternatively spliced to produce the M1 or M2 isoform. Pyruvate kinase M1 (PKM1) is predominantly expressed in adult tissues, while PKM2 is expressed during embryonic development. Tumor cells express exclusively PKM2 and PKM2 knockdown significantly impairs cancer growth.

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SPECIFICATIONS

Catalog Number

CABT-B1589

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Target

PKM

Gene Id

5315

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20В°C may cause glycerol containing solutions to become frozen during storage.

SUPPLIER INFO

Creative Diagnostics

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