Human Anti-Ribosomal P Antigen polyclonal antibody for ELISA. The Ribosomal P antigen consists of three proteins of the 60S ribosomal subunit. These three proteins are designated PO(38 kD), P1(19 kD), and P2(17 kD). Studies have suggested that one P1 homodimer and one P2 homodimer are attached to PO by the NH2-termini. P1 and P2 are believed to be the eukaryotic equivalent of the E. coli ribosomal protein L12 and have been shown to contain sequences that are highly conserved among eukaryotes. The major immunoreactive epitope of these ribosomal antigens has been mapped and is localized to the carboxy terminus. PO, P1, and P2 have an identical 17 amino acid carboxy terminus. The Ribosomal P antigens have GTPase activity and have been shown to be phosphorylated by casein kinase II. Autoantibodies to Ribosomal antigens were originally described inpatients with Systemic Lupus Erythematosus (SLE), and have been associated with psychotic episodes in SLE.
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