Anti-RIC8B polyclonal antibody

Rabbit Anti-Mouse RIC8B polyclonal antibody for WB, IP. Synembryn-B (UniProt Q80XE1; also known as Protein Ric-8B, Resistance to inhibitors of cholinesterase 8B) is encoded by the Ric8b (also known as BC051080) gene (Gene ID 237422) in murine species. Ric-8A and Ric-8B stimulate nucleotide exchange of all G? subunit classes by stabilizing the G? nucleotide-free transition state. Ric-8A acts upon G?i/q/13, while Ric-8B targets G?s/olf. In addition to their function as guanine nucleotide exchange factors (GEFs), Ric proteins also act as molecular chaperones that directly participate in the posttranslational folding of nascent G? subunits to promote G-protein biosynthesis and membrane association. Ric-8 knockdown reduces G? steady-state abundances and overexpression of Ric-8 proteins enhances cellular G? levels. In Ric-8AвЂ“ or Ric-8BвЂ“delicient ES cells, newly produced G? subunits are defective in the initial association with an internal membrane, resulting in a ?10-fold faster turned over rate than in WT cells.

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SPECIFICATIONS

Catalog Number

CABT-B1649

Hosts

Rabbit

Reactivities

Hum, Mouse, Rabbit

Target

RIC8B

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.