Mouse anti-Rodent Reelin monoclonal antibody for IF, ELISA, WB, IP. Reeler mice were the first animal mutants to be described with malformations of the cerebral cortex. The affected gene was cloned and named reelin (Reln). Reelin protein encoded by Reln gene is an extracellular matrix protein secreted by a variety of cell types throughout the developing brain. This protein is cleaved at two main locations, and almost no full length Reelin is detected in adult and embryonic brain extracts and body fluids. The main polypeptides being amino-terminal 180 kDa and the carboxy-terminal 100 kDa fragments. The central region of Reelin protein is essential for receptor binding and triggering of Dab1 phosphorylation. Target cells for reelin all express the cytoplasmic adapter protein Disabled 1 (Dab1), which binds to the reelin receptors, very-low-density lipoprotein receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2). These "reelin" receptors are located in developing mouse and human cortex, olfactory bulb and cerebellum. Neuronal migration is initially normal in the brains of reeler mice, but it seems that some cells do not recognize their proper location and orientation at the end of their migration pathway. The defect is most severe in the cerebral cortex, hippocampus and cerebellar cortex, but subtle anomalies have been identified at every location studied.
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