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anti-Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) (Internal Region) antibody

Cat no: ABIN1043879

anti-Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) (Internal Region) antibody

anti-Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) (Internal Region) antibody: ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2. The SLIT proteins are thought to act as a molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. ROBO-1 may also be required for lung development. ROBO-1 is a type I membrane protein. ROBO-1 is a widely expressed protein with the exception of the kidney. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. Multiple splice variants have been identified for this protein.

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SPECIFICATIONS

Catalog Number

ABIN1043879

Size

25 micro L

Applications

ELISA, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Can

Antigen

ROBO-1

Gene Id

6091,487690,19876,24906

Isotype

IgG

Clonality

Polyclonal

Entrez Gene Id

6091,487690,19876,24906

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