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Anti-RPS6KA1 (phospho T359/S363) polyclonal antibody

Cat no: CABT-B1946

Anti-RPS6KA1 (phospho T359/S363) polyclonal antibody

Rabbit Anti-Human RPS6KA1 polyclonal antibody for WB, Inhib, IHC, IP. Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1; UniProt Q15418; also known as 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, p90-RSK 1, p90RSK1, p90S6K, Ribosomal S6 kinase 1, RSK-1, S6K-alpha-1) is encoded by the RPS6KA1 (also known as MAPKAPK1A, RSK1) gene (Gene ID 6195) in human. Ribosomal s6 kinases (RSKs) are serine/threonine kinases that play a role in mediating Mek1/2-Erk1/2 mitogen-activated protein (MAP) kinase pathway signaling events. There exist two types of RSKs, p70rsk (a.k.a. S6 Kinase or S6-H1 kinase) and p90rsk (a.k.a. MAPK-activated protein kinase). Six p90rsk-coding genes have been identified in human, RPS6KA1 (MAPKAPK1A, RSK1), RPS6KA2 (MAPKAPK1C, RSK3), RPS6KA3 (MAPKAPK1B, RSK2), RPS6KA4 (MSK2), RPS6KA5 (MSK1), and RPS6KA6 (RSK4). Erk1/2 activates p90RSK1 by sequential phosphorylation events, where it first phosphorylates Rsk1 C-terminal kinase domain (CTKD) Thr573, leading to subsequent Ser380 phosphorylation in the N-terminal AGC kinase-type domain. Alternatively, Ser380 can be phosphorylated directly by MK2/3 independent of CTKD.

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SPECIFICATIONS

Catalog Number

CABT-B1946

Hosts

Rabbit

Reactivities

Hum

Target

RPS6KA1

Gene Id

6195

Clonality

Polyclonal

Storage Temp

Stable for 1 year at 2-8В°C from date of receipt.

SUPPLIER INFO

Creative Diagnostics

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

More info

Hosts

Mouse

Reactivities

Hum

Conjugates

Unconj

More info

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

More info

Hosts

Mouse

Reactivities

Hum

Conjugates

Unconj

More info

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

More info

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

More info

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

More info

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

More info

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